Discussion Board

Why COVID PCR tests aren't as accurate as you think

  • 1.  Why COVID PCR tests aren't as accurate as you think

    Posted 01-10-2021 09:39
    From Kevin MD, a clinician realizes that higher transmission rates are being driven by a lack of understanding of the role high false-negatives play in diagnosing COVID-19. If the RT-PCR high false negative rates are true in real world experience - and I believe them to be -then diagnostic error rates of SARS-COV-2 must be sky high. Will the CDC make changes in its diagnostic recommendations weighting clinical experience, patient symptoms, and history over test results? Where is the patient education, too?

    "According to a Johns Hopkins study, this so-called gold standard RT-PCR test can have a false negative up to 20 to 66 percent of the time in even symptomatic patients depending upon the test's timing. False negatives can be up to 100 percent on day one of exposure (asymptomatic) and down to 20 percent on day 8 of exposure (day 3 of symptoms) and then starts going up again. Statistics tell us that the false-negative rate goes up even higher as the prevalence of disease goes up, as is the case with COVID right now. A meta-analysis from Europe actually found an average false negative of 54 percent."