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Johns Hopkins / CRICO Release New SIDM-Funded "Big Three" Article on Misdiagnosis and Serious Harm Rates

  • 1.  Johns Hopkins / CRICO Release New SIDM-Funded "Big Three" Article on Misdiagnosis and Serious Harm Rates

    Posted 05-14-2020 12:08
    Edited by Amanda Staller 05-14-2020 16:29

    Dear Friends & Colleagues,


    I hope all of you are staying as safe as possible in these trying times.


    I am happy to share our team's latest research (https://www.degruyter.com/view/journals/dx/ahead-of-print/article-10.1515-dx-2019-0104/article-10.1515-dx-2019-0104.xml), published today in Diagnosis, detailing the rate of diagnostic errors for "Big Three" disease conditions causing serious misdiagnosis-related harms.


    Our teams at Johns Hopkins and CRICO found that one in 10 patients (9.6%) with a "Big Three" condition-i.e., major vascular event, infection, or cancer-will be misdiagnosed. Diagnostic error rates derive from studies describing over 90,000 patients with one of the top 5 diseases in each Big Three category and were vetted by nearly two dozen disease-specific clinical domain experts. Among patients with one of these 15 disorders whose diagnoses are initially missed or delayed, best available evidence suggests that about half (53.9%) likely suffer a permanent disability or death because of the error.


    This new research, funded by the Society to Improve Diagnosis in Medicine through a grant from the Gordon and Betty Moore Foundation evolves and builds upon our understanding of how and when inaccurate and delayed diagnoses happen. Previous research (https://www.degruyter.com/view/journals/dx/6/3/article-p227.xml) found that more than one in three malpractice cases resulting in serious harms was due to inaccurate or delayed diagnoses, defined these Big Three categories, and showed that harms for the 15 Big Three conditions likely represent about half of all the serious, misdiagnosis-related harms across all diseases.


    Wishing health to all of you and your loved ones.



    David (on behalf of Dana Siegal, my co-corresponding author, and the rest of the "Big Three" team members at Johns Hopkins and CRICO)



    David E. Newman-Toker, MD PhD

    Professor of Neurology, Ophthalmology, & Otolaryngology

    Director, Division of Neuro-Visual & Vestibular Disorders

    Director, Armstrong Institute Center for Diagnostic Excellence

    Co-Director, Center for Mobile Technologies to Achieve Equity in Cardiovascular Health

    Core Faculty, Brain Injury OutcomeS (BIOS) Clinical Trials Unit

    President, Society to Improve Diagnosis in Medicine


    Johns Hopkins University School of Medicine
    Johns Hopkins Hospital; Pathology Building 2-221

    600 North Wolfe Street; Baltimore, MD 21287-6921


    Administrator: Myriha Wrencher 410-361-7981; mmontg20@jhmi.edu

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  • 2.  RE: Johns Hopkins / CRICO Release New SIDM-Funded "Big Three" Article on Misdiagnosis and Serious Harm Rates

    Posted 05-14-2020 15:57
    The link to the article and wrong and delayed DX are wrong or delayed. They say they don't work.  Please send a functioning link to this very important article.
    Thank you.


    Prof. of Biomedical Informatics, Perelman Sch of Medicine.

    Senior Fellow, Wharton's Leonard Davis Institute of Healthcare Economics;    

    Senior Fellow, Center for Public Health Initiatives, Perelman Sch of Medicine; 

    Adjunct Professor (full) Sociology Department;    

    Affil Prof of Medicine, Perelman Sch of Medicine;  

    Prof. of Biomedical Informatics, SUNY@Buffalo    


  • 3.  RE: Johns Hopkins / CRICO Release New SIDM-Funded "Big Three" Article on Misdiagnosis and Serious Harm Rates

    Posted 05-14-2020 17:03


    Sorry to those having trouble with the links –


    Please try these:


    May 14 research: https://www.degruyter.com/view/journals/dx/ahead-of-print/article-10.1515-dx-2019-0104/article-10.1515-dx-2019-0104.xml
    July 11 research: https://www.degruyter.com/view/journals/dx/6/3/article-p227.xml





    Lorie Slass
    Vice President of Communications and Marketing
    Society to Improve Diagnosis in Medicine (SIDM)
    Phone: 215.801.4057