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Actual method of diagnosis in practice

  • 1.  Actual method of diagnosis in practice

    Posted 06-25-2021 11:02
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    In the attached paper, I discuss that the method actually employed for diagnosis in practice is the frequentist confidence method. The important features of this method are as follows:
    1. The probability of a disease is interpreted as its frequency derived from observation in a random sample.
    2. This probability as a frequency is attached to a procedure for inferring (diagnosing) a disease in any patient regardless of prior probability of disease.
    3. Usually a highly informative test result with likelihood ratio greater than 10 is employed for inference of a disease with a high degree of accuracy in patients with varying prior probabilities all over the world.
    4. I illustrate this method with the example of diagnosis of acute myocardial infarction in practice.
    Please review and comment on this paper.


    Bimal Jain MD
    Mass General Brigham/Salem Hospital
    Salem MA 01970
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